A strange question. Has anyone here had MTF gender dysphoria, started taking estrogen based HRT, and then stopped, and after having stopped, their dysphoria was resolved? (Details in post)

I had an odd case recently, and it made me wonder if this is something that often happens, and I'm simply oblivious to it because the people don't follow up. They are effectively "cured" and don't come back.

Part of neurological masculinization is late term estrogen exposure, defeminizing the fetal brain. Failures in estrogen signaling pathways are one of the ways to produce a MTF trans person.

This is actually one of the reasons why Diethylstilbestrol exposure may be associated with hypospadias and homosexuality, but in DES exposed males, there is a DECREASED amount of gender dysphoria compared to the background population.

(Its also a crackpot theory of mine why a lot of dudebros who go to the gym and juice get such bad gyno, as they have powerful aromatase activity, which helped supermasculinize them in utero, making them that kind of gymbro chad mentally, but as adults, causes them gyno when on 'roids).

Its generally assumed that this estrogen signaled masculinization window closes and that's it. As if it didnt, giving estrogen to MTFs would make them feel masculine. Clearly that is not the case most of the time.

But I wonder if that's always the case. Has there been anyone here who basically had dysphoria, started on HRT, ran it for awhile, stopped for whatever reason, and then after cessation, no longer felt dysphoria anymore? That was it, it just ended? They felt cis and masculine after taking it?

I know this is an odd one, and that person is probably not on this subreddit browsing here, but if you're aware of someone this matches, and you could share this with them, I'd appreciate it. I'm continuing to try and look at my pile of genomes and use AI tools and do what I can to try and elucidate the biochemical mechanisms of gender dysphoria and consider all possible means of treatment.

Thanks as always fam,

-Dr P