What are your run killers?

We all know what I’m talking about… Your best colonist sad wanders into a bug hive and dies! Running out of steel late game and halts everything! and can’t be bothered waiting for traders or setting up minding colonies. Mod conflicts that are made apparent late into the game that brick everything.

Not just things that actually end up with everyone dying. But stuff that erks you or can’t stand ends up happening that kills your motivation to continue. Quitting runs halfway though happens all the time in Rimworld, is that true for you?